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Deoxo-Fluor™ |
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Deoxo-Fluor™ Fluorinating Reagent
The Deoxo-FluorTM reagent is a versatile, easy-to-use, nucleophilic fluorinating reagent with enhanced safety features. It rapidly "deoxofluorinates" a wide variety of alcohols, aldehydes, and ketones under mild conditions to yield the corresponding fluorinated compounds with high efficiency and selectivity. Deoxo-FluorTM is thermally less sensitive than DAST, the traditional deoxofluorinating agent and is thus more amenable to large-scale use. See Summary of Applications and Thermal Stability Data.
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- Highly selective
- Cost efficient
- Easy to use; Enhanced safety
- Stable liquid
- Converts C-O to C-F
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Summary of Properties and Special Features
Physical Properties
| Molecular Formula |
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(CH3OCH2CH2)2NSF3 |
| Molecular Weight |
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221.23 g/mol |
| Appearance |
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Dark Yellow Liquid at Room Temp. |
| Melting Point |
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Not Determined |
| Boiling Point |
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60 °C (10mm/Hg) |
| Flash Point |
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No Flash Observed up to 100 °C |
| Density |
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1.2 g/mL |
Chemical Properties
| Reactivity |
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Alcohols, Aldehydes, and Ketones
Reacts violently with H2O to form HF |
| Activity for C-OH |
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85.9 g of F/Kg of Deoxo-FluorTM
4.5 mmol of F/g of Deoxo-FluorTM |
| C=O |
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171.8g of F/Kg of Deoxo-FluorTM
9.0 mmol of F/G of Deoxo-FluorTM |
| Purity |
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>95% F-Active |
| Solubility |
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Hexane, Ethers, Halogenated Organics, Toluene, and other common organic solvents |
| Compatibility |
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Stainless Steel, Hastelloy, Monel, (glass not recommended) |
| Stability |
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Stable at room temperature in the absence of moisture |
| Decomposition |
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>95 °C by ARC |
Safety Precautions
| Storage |
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For long-term storage, refrigerate and store under nitrogen |
| Handling |
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Work in an inert, anhydrous atmosphere |
| Precautions |
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Harmful if swallowed, inhaled, or absorbed through the skin |
| First Aid Measures |
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Flush eyes and skin with copious amounts of water for at least 15 minutes. Contact a physician |
Summary of Fluorination Applications of Deoxo-FluorTM
Note: The information is in PDF format. You will need the free Adobe Acrobat Reader to view this information.
Comparison of the Thermal Stability of Deoxo-Fluor™ and DAST Reagents
Click here to view document (PDF, 11K)
References for Deoxo-Fluor
- G. S. Lal, G. P. Pez, R. J. Pesaresi and F. M. Prozonic, Chem. Commun., 216-216, 1999.
- G. S. Lal, G. P. Pez, R. J. Pesaresi. F. M. Prozonic and H. Cheng, J. Org. Chem., 7048-7054, 1999.
- G. S. Lal, E. Lobach and A. Evans, J. Org. Chem., 4830-4832, 2000.
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