Preserve sensitive, high-value materials (such as biologic formulations, vaccines, starter cultures and non-aqueous solvent-based drugs) through freeze drying (lyophilization) by first freezing them with liquid nitrogen, which results in ultra-low temperatures, and then dehydrating them in a vacuum.
This is the best way to preserve materials that cannot withstand oxygen or heat, or materials that lose activity as a liquid – enabling them to remain highly stable in their dehydrated form. Examples include antibiotics, vaccines, blood products, protein, antibodies, enzymes, bacteria, viruses, and fine chemicals.
Liquid nitrogen can be economically and successfully used instead of mechanical refrigeration for lyophilization/pre-freezing, resulting in increased viability and yield. It also helps improve performance and reliability and can involve lower capital investment compared to mechanically based systems.